Our goal is to understand mechanisms of resistance and discover potential molecular targets in leukemia to develop and propose novel therapies, with special interest in intercellular interactions and their role within the leukemia microenvironment.

We focus on investigation of the cytoprotective pathways, stress response and DNA repair mechanisms in order to propose and verify novel prospective targets and potential therapeutic treatments, including personalized therapies.  A high priority is to understand the intercellular cross-talk between the leukemic and surrounding cells and the role of leukemia microenvironment - bone marrow stroma or immune system cells in development of disease and resistance. 

We achieve these aims in in vitro and in vivo models by studies at the genomic, proteomic and cellular levels, together with a diverse array of techniques, ranging from biochemical and molecular biology methods to cellular biology, multicolor flow cytometry, cell sorting and microscopy techniques, including confocal, EM, SEM, CLEM to visualize cellular processes and molecules. 

Currently we investigate: 

Integrated Stress Response pathways in leukemia

Non-classical mechanisms of BRCA1/2 deficiencies in leukemia and sensitivity to personalized therapy by PARP inhibitors

The leukemia-bone marrow stroma interactions

Direct intercellular connections within leukemia microenvironment by tunneling nanotubes (TNTs) 

Leukemic extracellular vesicles and influence on immunosuppression   

Protein markers for BRCA1/2 deficiency and PARP1 inhibitors in cancer 

For details go to the Research.

Our mission is to provide leading edge service, expertise and instrumentation in flow cytometry for in-house and outside investigators. Our vision is to meet reserchers' specific needs by providing dedicated help with design of experiments, aquisition and data analysis.

We offer the state-of-the-art expertise in flow cytometry and sorting, with a wide range of flow cytometry techniques, hands-on service, data analysis and training.  We are also involved in the research and innovative projects, based on the high-tech flow cytometry applications. We are using modern flow cytometry applications to study different cellular processes, immune cells subsets, rare events, apoptosis, proliferation, signal transduction, ROS production and many others. One of our big expertise is cell sorting, including sorting from demanding tissues, e.g. microglia or organisms, e.g. zebrafish. Additionally we perform single-cell sorting into the 96-well plates or microscope slides. Our goal is to meet reserchers' specific needs by providing dedicated help with design of experiments, aquisition and data analysis. 

Lab members provide training, organize courses and workshops in basic and advanced flow cytometry techniques. Being part of the ISAC (International Society for Advancement of Cytometry) Life Education Task, we organize ISAC Warsaw Workshops. We participate in the ISAC  initiatives to provide opportunities for collaboration with expertise laboratories.