Publications

PUBLICATIONS

2020

Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. eLife 2020; 9:e58504. Published online 2020 Aug 14. doi: 10.7554/eLife.58504. PMID: 32795391


Swatler J, Dudka W, Bugajski L, Brewinska-Olchowik M, Kozlowska E, Piwocka K. Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells. Eur J Immunol. 2020 Apr;50(4):606-609. doi: 10.1002/eji.201848051. Epub 2019 Dec 5. PubMed PMID: 31758697


Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M. Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. EMBO Mol Med. 2020 Feb 7;12(2):e10812. doi: 10.15252/emmm.201910812. Epub 2020 Jan 13. PubMed PMID: 31930723.


2019

Swatler J, Dudka W, Bugajski L, Brewinska-Olchowik M, Kozlowska E, Piwocka K. Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells. Eur J Immunol. 2019 Nov 23. doi: 10.1002/eji.201848051. [Epub ahead of print] PubMed PMID: 31758697.


Kolba MD, Dudka W, Zaręba-Kozioł M, Kominek A, Ronchi P, Turos L, Chroscicki P, Wlodarczyk J, Schwab Y, Klejman A, Cysewski D, Srpan K, Davis DM, Piwocka K. Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells. Cell Death Dis. 2019 Oct 28;10(11):817. doi: 10.1038/s41419-019-2045-8. PubMed PMID: 31659149; PubMed Central PMCID: PMC6817823.


Ochocka N, Segit P, Walentynowicz KA, Wojnicki K, Cyranowski S, Swatler J, Mieczkowski J and Kaminska B. Single-cell RNA Sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages. bioRxiv. 2019 Aug 30: 752949. doi:10.1101/752949


Świerczek-Lasek B, Neska J, Kominek A, Tolak Ł, Czajkowski T, Jańczyk-Ilach K, Stremińska W, Piwocka K, Ciemerych MA, Archacka K. Interleukin 4 Moderately Affects Competence of Pluripotent Stem Cells for Myogenic Conversion. Int J Mol Sci. 2019 Aug 13;20(16). pii: E3932. doi: 10.3390/ijms20163932. PubMed PMID: 31412558; PubMed Central PMCID: PMC6720909.


Fedorczyk B, Lipiński PFJ, Puszko AK, Tymecka D, Wilenska B, Dudka W, Perret GY, Wieczorek R, Misicka A. Triazolopeptides Inhibiting the Interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165. Molecules. 2019 May 6;24(9). pii: E1756. doi: 10.3390/molecules24091756. PubMed PMID: 31064153; PubMed Central PMCID: PMC6539594.


Pawlak M, Kedzierska KZ, Migdal M, Nahia KA, Ramilowski JA, Bugajski L, Hashimoto K, Marconi A, Piwocka K, Carninci P, Winata CL. Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development. Genome Res. 2019 Mar;29(3):506-519. doi: 10.1101/gr.244491.118. Epub 2019 Feb 13. PubMed PMID: 30760547; PubMed Central PMCID: PMC6396412.


2018

Piwocka K, Podszywałow-Bartnicka P, Skorski T. BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters. Postepy Biochem. 2018 Oct 15;64(2):141-147. doi: 10.18388/pb.2018_124. Review. PubMed PMID: 30656896.


Nieborowska-Skorska M, Maifrede S, Ye M, Toma M, Hewlett E, Gordon J, Le BV, Sliwinski T, Zhao H, Piwocka K, Valent P, Tulin AV, Childers W, Skorski T. Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia. Leuk Lymphoma. 2019 Apr;60(4):1098-1101. doi: 10.1080/10428194.2018.1520988. Epub 2018 Oct 2. PubMed PMID: 30277116; PubMed Central PMCID: PMC6445778.


Ulanska-Poutanen J, Mieczkowski J, Zhao C, Konarzewska K, Kaza B, Pohl HB, Bugajski L, Kaminska B, Franklin RJ, Zawadzka M. Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells. Elife. 2018 Sep 17;7. pii: e30325. doi: 10.7554/eLife.30325.


Podszywalow-Bartnicka P, Kominek A, Wolczyk M, Kolba MD, Swatler J, Piwocka K. Characteristics of live parameters of the HS-5 human bone marrow stromal cell line cocultured with the leukemia cells in hypoxia, for the studies of leukemia-stroma cross-talk. Cytometry A. 2018 Jul;93(9):929-940. doi: 10.1002/cyto.a.23580. Epub 2018 Sep 3. PubMed PMID: 30247803.


Podszywalow-Bartnicka P, Maifrede S, Le BV, Nieborowska-Skorska M, Piwocka K, Skorski T. PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions. Leuk Lymphoma. 2019 Jan;60(1):262-264. doi: 10.1080/10428194.2018.1471602. Epub 2018 Jun 22. PubMed PMID: 29932782; PubMed Central PMCID: PMC6309580.


Maifrede S, Nieborowska-Skorska M, Sullivan-Reed K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Toma M, Chatain N, Rydzanicz M, Zhao H, Jelinek J, Piwocka K, Sliwinski T, Stoklosa T, Ploski R, Fischer T, Sykes SM, Koschmieder S, Bullinger L, Valent P, Wasik MA, Huang J, Skorski T. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. Blood. 2018 Jul 5;132(1):67-77. doi: 10.1182/blood-2018-02-834895. Epub 2018 May 21. PubMed PMID: 29784639; PubMed Central PMCID: PMC6034642.


Bem J, Grabowska I, Daniszewski M, Zawada D, Czerwinska AM, Bugajski L, Piwocka K, Fogtman A, Ciemerych MA. Transient MicroRNA Expression Enhances Myogenic Potential of Mouse Embryonic Stem Cells. Stem Cells. 2018 May;36(5):655-670. doi: 10.1002/stem.2772. Epub 2018 Jan 22. PubMed PMID: 29314416.


2017

Maifrede S, Martinez E, Nieborowska-Skorska M, Di Marcantonio D, Hulse M, Le BV, Zhao H, Piwocka K, Tempera I, Sykes SM, Skorski T. MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs. Blood Adv. 2017 Aug 9;1(19):1467-1472. doi: 10.1182/bloodadvances.2017006247. eCollection 2017 Aug 22. PubMed PMID: 29296788; PubMed Central PMCID: PMC5728460.


Was H, Czarnecka J, Kominek A, Barszcz K, Bernas T, Piwocka K, Kaminska B. Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. Cancer Biol Ther. 2018 Jan 2;19(1):63-75. doi: 10.1080/15384047.2017.1385675. Epub 2017 Dec 22. PubMed PMID: 29053388; PubMed Central PMCID: PMC5790359.


Asosingh K, Piwocka K, Schildberg FA. New developments in cytometric phenotyping. Cytometry A. 2017 Oct;91(10):950-951. doi: 10.1002/cyto.a.23262. PubMed PMID: 29048778.


Nieborowska-Skorska M, Maifrede S, Dasgupta Y, Sullivan K, Flis S, Le BV, Solecka M, Belyaeva EA, Kubovcakova L, Nawrocki M, Kirschner M, Zhao H, Prchal JT, Piwocka K, Moliterno AR, Wasik M, Koschmieder S, Green TR, Skoda RC, Skorski T. Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms. Blood. 2017 Dec 28;130(26):2848-2859. doi: 10.1182/blood-2017-05-784942. Epub 2017 Oct 17. PubMed PMID: 29042365; PubMed Central PMCID: PMC5746670.


Wesołowska A, Piwocka K. [Exosomal microRNAs as a part of the cell-cell communication in cancer]. Postepy Biochem. 2017;63(2):110-118. Review. Polish. PubMed PMID: 28689377.


Bieńkowska A, Kiernozek E, Kozlowska E, Bugajski L, Drela N. A new approach to the role of IL-7 and TGF-ß in the in vitro generation of thymus-derived CD4+CD25+Foxp3+ regulatory T cells. Cytokine. 2017 Aug 18. pii: S1043-4666(17)30219-3. doi: 10.1016/j.cyto.2017.07.019. PMID: 28826649


Maifrede S, Martin K, Podszywalow-Bartnicka P, Sullivan-Reed K, Langer SK, Nejati R, Dasgupta Y, Hulse M, Gritsyuk D, Nieborowska-Skorska M, Lupey-Green LN, Zhao H, Piwocka K, Wasik MA, Tempera I, Skorski T. IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. Mol Cancer Res. 2017 Aug;15(8):967-972. doi: 10.1158/1541-7786.MCR-16-0468. Epub 2017 Jun 20. PubMed PMID: 28634224; PubMed Central PMCID: PMC5540764.


Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017 Jun 1;127(6):2392-2406. doi: 10.1172/JCI90825. Epub 2017 May 8. PubMed PMID: 28481221; PubMed Central PMCID: PMC5451241.


Wolczyk M, Podszywalow-Bartnicka P, Bugajski L, Piwocka K. Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1024-1035. doi: 10.1016/j.bbagen.2017.02.010. Epub 2017 Feb 13. PubMed PMID: 28196667.


Was H, Barszcz K, Czarnecka J, Kowalczyk A, Bernas T, Uzarowska E, Koza P, Klejman A, Piwocka K, Kaminska B, Sikora E. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Oncotarget. 2017 Feb 7;8(6):9303-9322. doi: 10.18632/oncotarget.14066. PubMed PMID: 28030837; PubMed Central PMCID: PMC5354733.


2016

Mikuła-Pietrasik J, Uruski P, Sosińska P, Maksin K, Piotrowska-Kempisty H, Kucińska M, Murias M, Szubert S, Woźniak A, Szpurek D, Sajdak S, Piwocka K, Tykarski A, Książek K. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016 Dec 29;7(12):e2565. doi: 10.1038/cddis.2016.417. PubMed PMID: 28032864; PubMed Central PMCID: PMC5261005.


Podszywalow-Bartnicka P, Cmoch A, Wolczyk M, Bugajski L, Tkaczyk M, Dadlez M, Nieborowska-Skorska M, Koromilas AE, Skorski T, Piwocka K. Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes. Oncotarget. 2016 Nov 29;7(48):79706-79721. doi: 10.18632/oncotarget.12941. PubMed PMID: 27802179; PubMed Central PMCID: PMC5346746.


Piwocka K. When polychromatic flow cytometry meets mitochondrial reactive oxygen species. Cytometry A. 2016 Dec;89(12):1052-1053. doi: 10.1002/cyto.a.22980. Epub 2016 Sep 15. PubMed PMID: 27632791.


Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M. ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors. Sci Signal. 2016 Jan 19;9(411):ra8. doi: 10.1126/scisignal.aad0848. PubMed PMID: 26787452.


2015

Kalaidzidis I, Miaczynska M, Brewińska-Olchowik M, Hupalowska A, Ferguson C, Parton RG, Kalaidzidis Y, Zerial M. APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments. J Cell Biol. 2015 Oct 12;211(1):123-44. doi: 10.1083/jcb.201311117, PMID: 26459602

Mikuła-Pietrasik J, Sosińska P, Murias M, Wierzchowski M, Brewińska-Olchowik M, Piwocka K, Szpurek D, Książek K. High Potency of a Novel Resveratrol Derivative, 3,3',4,4'-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair. Oxid Med Cell Longev. 2015;2015:135691. doi: 10.1155/2015/135691. Epub 2015 Jul 1. PubMed PMID: 26229578; PubMed Central PMCID: PMC4502315.


Wylot B, Konarzewska K, Bugajski L, Piwocka K, Zawadzka M. Isolation of vascular endothelial cells from intact and injured murine brain cortex-technical issues and pitfalls in FACS analysis of the nervous tissue. Cytometry A. 2015 Oct;87(10):908-20. doi: 10.1002/cyto.a.22677. Epub 2015 Apr 17. PubMed PMID: 25892199.


Pavlyk I, Rzhepetskyy Y, Jagielski AK, Drozak J, Wasik A, Pereverzieva G, Olchowik M, Kunz-Schugart LA, Stasyk O, Redowicz MJ. Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation. Amino Acids. 2015 Jan;47(1):199-212. doi: 10.1007/s00726-014-1857-1. PMID: 25362567


2014

Podszywalow-Bartnicka P, Wolczyk M, Kusio-Kobialka M, Wolanin K, Skowronek K, Nieborowska-Skorska M, Dasgupta Y, Skorski T, Piwocka K. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation. Cell Cycle. 2014;13(23):3727-41. doi: 10.4161/15384101.2014.965013. PubMed PMID: 25483082.


Piwocka K, Dekker FJ. Inhibition of p53 acetylation by PCAF inhibitor anacardic acid derivative in BCR-ABL1-expressing cells.; breaking resistance to DNA damage and possible therapeutical implications. World Biomedical Frontiers; Cancer- 2014-3-8. ISSN, 2328-0166


Winiarska M, Bojarczuk K, Pyrzynska B, Bil J, Siernicka M, Dwojak M, Bobrowicz M, Miazek N, Zapala P, Zagozdzon A, Krol M, Syta A, Podszywalow-Bartnicka P, Pilch Z, Dabrowska-Iwanicka A, Juszczynski P, Efremov DG, Slabicki M, Zenz T, Roy AL, Olive D, Rygiel TP, Leusen JH, Golab J. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies. MAbs. 2014 Sep 3;6(5):1300-13. doi: 10.4161/mabs.32106. PMID: 25517315


Jaworska-Wilczyńska M, Magalska A, Piwocka K, Szymański P, Kuśmierczyk M, Wąsik M, Hryniewiecki T. Low interleukin-8 level predicts the occurrence of the postpericardiotomy syndrome. PLoS One. 2014 Oct 21;9(10):e108822. doi: 10.1371/journal.pone.0108822. eCollection 2014. PubMed PMID: 25333927; PubMed Central PMCID: PMC4204829.


Cmoch A, Podszywalow-Bartnicka P, Palczewska M, Piwocka K, Groves P, Pikula S. Stimulators of mineralization limit the invasive phenotype of human osteosarcoma cells by a mechanism involving impaired invadopodia formation. PLoS One. 2014 Oct 14;9(10):e109938. doi: 10.1371/journal.pone.0109938. eCollection 2014. PubMed PMID: 25314307; PubMed Central PMCID: PMC4196965.


Alster O, Bielak-Zmijewska A, Mosieniak G, Moreno-Villanueva M, Dudka-Ruszkowska W, Wojtala A, Kusio-Kobiałka M, Korwek Z, Burkle A, Piwocka K, Siwicki JK, Sikora E. The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes. PLoS One. 2014 Aug 13;9(8):e104964. doi: 10.1371/journal.pone.0104964. eCollection 2014. PubMed PMID: 25119968; PubMed Central PMCID: PMC4132076.


Kosiorek M, Podszywalow-Bartnicka P, Zylinska L, Pikula S. NFAT1 and NFAT3 cooperate with HDAC4 during regulation of alternative splicing of PMCA isoforms in PC12 cells. PLoS One. 2014 Jun 6;9(6):e99118. doi: 10.1371/journal.pone.0099118. PMID: 24905014


Dymkowska D, Drabarek B, Podszywałow-Bartnicka P, Szczepanowska J, Zabłocki K. Hyperglycaemia modifies energy metabolism and reactive oxygen species formation in endothelial cells in vitro. Arch Biochem Biophys. 2014 Jan 15;542:7-13. doi: 10.1016/j.abb.2013.11.008. PMID: 24295959

2013

Mikuła-Pietrasik J, Sosińska P, Wierzchowski M, Piwocka K, Książek K. Synthetic resveratrol analogue, 3,3',4,4',5,5'-hexahydroxy-trans-stilbene, accelerates senescence in peritoneal mesothelium and promotes senescence-dependent growth of gastrointestinal cancers. Int J Mol Sci. 2013 Nov 14;14(11):22483-98. doi: 10.3390/ijms141122483. PubMed PMID: 24240809; PubMed Central PMCID: PMC3856075.


Mikuła-Pietrasik J, Sosińska P, Janus J, Rubiś B, Brewińska-Olchowik M, Piwocka K, Książek K. Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1. Int J Biochem Cell Biol. 2013 Sep;45(9):2087-96. doi: 10.1016/j.biocel.2013.07.004. Epub 2013 Jul 17. PubMed PMID: 23871936.


Kusio-Kobialka M, Dudka-Ruszkowska W, Ghizzoni M, Dekker FJ, Piwocka K. Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells. Anticancer Agents Med Chem. 2013 Jun;13(5):762-7. PubMed PMID: 23157591.


2012

Kusio-Kobialka M, Podszywalow-Bartnicka P, Peidis P, Glodkowska-Mrowka E, Wolanin K, Leszak G, Seferynska I, Stoklosa T, Koromilas AE, Piwocka K. The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells. Cell Cycle. 2012 Nov 1;11(21):4069-78. doi: 10.4161/cc.22387. Epub 2012 Oct 24. PubMed PMID: 23095523; PubMed Central PMCID: PMC3507502.


Kusio-Kobialka M, Wolanin K, Podszywalow-Bartnicka P, Sikora E, Skowronek K, McKenna SL, Ghizzoni M, Dekker FJ, Piwocka K. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis. 2012 Sep;17(9):950-63. doi: 10.1007/s10495-012-0739-9. PubMed PMID: 22696202.