The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of: Postdoctoral Researcher
Number of available positions: 1
Place of work: Nencki Institute of Experimental Biology, Polish Academy of Sciences
Researcher career profiles: R2
Field of science: life sciences, biomedical sciences
Type of recruitment: National Science Centre OPUS grant
We are seeking for highly motivated postdoctoral researcher to study novel personalized therapeutic strategy for myeloid neoplasms with PTPN11 mutations.
Doctoral degree in the field of biology, biomedical, medical, immunology sciences, obtained not earlier than 7 years before the year of employment in the project (not including maternity leaves).
Experience conducting laboratory work within the areas of cell/cancer/leukemia biology, immunology, with the use of cancer/leukemia mouse models, documented by a publication record
An important criterion in the selection will also be expertize in immunology, cytometry, working with mouse models
Bioinformatic skills will be an advantage
High motivation, creativity and ability to independently plan and execute research experiments
Scientific achievements documented by publications in journals from the JCR list
Two recommendation letters
Team work skills
Scope of tasks: Recruted postdoctoral researcher will be involved in realization of the National Science Centre OPUS grant: Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms with PTPN11 mutations.
Myeloid neoplasms, especially highly heterogeneous Acute Myeloid Leukemia (AML), represent the most common types of leukemia in adults. Very little improvement in survival has been achieved over the past decades. Personalized therapies designed for selected patients identified by genetic screen and specific targeted treatment seem to be the best current strategy. Our project addresses major needs to develop novel therapies for myeloid 2 malignancies with PTPN11 mutations, characterized by high resistance and bad clinical outcomes. Previously we have identified prosurvival signaling which can be a novel potential target for effective therapy of resistance leukemia. Those studies will investigate therapeutic strategy based on targeting of stress signaling together with driver oncoproteins, include investigation of potential drugs and verify the effects of the new personalized therapy on prosurvival signaling, immunosuppression, stroma-mediated protection and finally leukemia development and sensitivity to treatment. Postdoc will be involved in implementation of the novel syngenic leukemia mouse model based on genetically modified cells, studies using PDX in vivo models / immunodeficient mice, verification of the proposed therapeutic strategy on the immunosupression and activity of immune cells subsets by using sc-RNAseq, scmultiparameter (25-30 parameters) spectral polychromatic cytometry with unsupervised data analysis , as well as signal transduction and cell biology and in vivo/ in vitro imaging studies.
1. Dudka et al., Targeting Integrated Stress Response by ISRIB combined with imatinib attenuates STAT5 signaling and eradicates therapy-resistant Chronic Myeloid Leukemia cells. bioRxiv 2021.05.05.442756; doi: https://doi.org/10.1101/2021.05.05.442756
2. Swatler et al., 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells. Blood Adv. 2022 Feb 7:bloodadvances.2021006195. https://doi:10.1182/bloodadvances.2021006195
3. Kusio-Kobialka M, Podszywalow-Bartnicka P, Peidis P, Glodkowska-Mrowka E, Wolanin K, Leszak G, Seferynska I, Stoklosa T, Koromilas AE, Piwocka K. The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells. Cell Cycle. 2012 Nov 1;11(21):4069-78. https://doi:10.4161/cc.22387
Further information can be obtained by contacting Katarzyna Piwocka (firstname.lastname@example.org).
Link to website: www.nencki.edu.pl https://piwocka-lab.nencki.edu.pl/
type of contract: full-time employment contract
duration of contract: 3 years (after trial period)
Application procedure and deadline:
Closing date for applications: 15.03.2022
Applications should be sent to email@example.com with note “postdoc OPUS KP” in the email title.
Work in a young, science-driven multidisciplinary team in an excellent scientific environment Access to the state-of-the-art equipment and facilities.
The laboratory is located at the at the Nencki Institute of Polish Academy of Sciences in 3 Warsaw, Poland, which offers a vibrant, international scientific community: https://www.nencki.edu.pl/; https://piwocka-lab.nencki.edu.pl/
Collaboration with scientific, medical and R&D institutions International collaboration and external trainings abroad
Participation in courses and conferences
CV with description of professional experience and list of publications
Contact information for 3 persons who can provide references /3 references
Copy of PhD diploma (or equivalent)
Contact information, including e-mail address and phone number
You can use the foreign equivalent of a Polish academic degree if it meets at least one of the following criteria:
is covered by the provisions of an international agreement on the equivalence of education,
was issued by an authorized institution operating in an EU, OECD or EFTA Member State,
was issued in another country and recognized on the basis of the regulations on the recognition of academic degrees obtained abroad (learn more about the procedure for the recognition of academic degrees: https://nawa.gov.pl/en/recognition/recognition-for-professionalpurposes/recognition-of-scientific-degrees-and-titles
Please include the following clause in your CV: “I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for postdoctoral position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).”
The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3.
Contact Details of the Personal Data Protection Officer: firstname.lastname@example.org
Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for post-doc position conducted by Nencki Institute of Experimental Biology PAS. Giving consent for processing of your personal data is voluntary; however, it is necessary in order to take part in recruitment. I hereby state that I was informed about the right to withdraw my consent at any time. The withdrawal of the consent does not influence the lawfulness of any processing performed before the consent withdrawal. 4 Personal data collected in order to perform the recruitment process shall be processed throughout the period of time necessary for the organisation and completion of the recruitment process, as well as for considering a possible complaint; however, not longer than up to 31.05.2022.
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